Unlocking the Potential of Biomacromolecules: A Journey from Novel Drug Delivery Systems to Regenerative Medicine
17 March 2023
Prof. Stefan Schiller
Stefan Schiller is a professor at the Institute of Pharmaceutical Technology at the Goethe University Frankfurt. He obtained his education in chemistry from Justus-Liebig University Gießen, Johannes Gutenberg University Mainz, and the University of Massachusetts, Amherst, USA. He has a diploma in bioorganic chemistry and earned his doctorate in bioorganic chemistry with a focus on biomimetic membranes from Johannes Gutenberg University/Max Planck Institute for Polymer Research, the IBM Research Center Almaden, San Jose, and Stanford University. He completed his postdoctoral research in chemical and synthetic biology with Prof. Peter G. Schultz at The Scripps Research Institute, La Jolla, California, USA. As a Junior Research Fellow, he is leading an independent research group at the Albert-Ludwigs-University/Freiburg and the Freiburg Institute for Advanced Studies (FRIAS).
Precision molecules are inevitable to design and control biological function in pharmacy and medicine. Proteins as tectons (architectural building blocks) enable high molecular precision using various design approaches. Here the use of designable structural protein motives derived from elastin-like proteins are used to create a modular library of over 800 sequence building blocks enabling access to block-domain proteins for: I) amphiphilic proteins mimicking the function of membrane phospholipids – with uses for novel drug formulation strategies and the design of de novo organelles and protocells. II) adaptive material properties used in 4D printing and the creation of artificial extracellular protein matrices for applications in tissue replacement and wound-closure.