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Characterization of naturally occurring flavivirus host-specific mutations

In 2016, Zika virus (ZIKV) infected millions with instances of neurological and congenital complications. ZIKV, like most RNA viruses, has an error-prone RNA-dependent RNA polymerase (RdRp) leading to numerous mutations over a single infection. Herein, we identified common intrahost mutations from Nicaragua during the epidemic. They were evaluated for replicative potential and three exhibited growth advantages. We then examined the underlying mechanisms by cellular transcriptomics, namely immunological and physiological disturbance. Lastly, we illustrated their ability to change the growth phenotypes of the closely related dengue virus (DENV). Together, we demonstrated the enormous potential of intrahost microevolution with single-point conversions.

Power in Numbers

Liu Ruyue


[object Object]


15 February 2024


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