Impact of Compaction Parameters on MUPS Tablet Properties

Multi-unit pellet system (MUPS) tablets provide a multitude of advantages for sustained release dosage forms. However, with the need to be tabletted, one major challenge is compaction induced pellet coat damage which undermines the desired sustained release function. Many strategies have been evaluated to mitigate the issue of coat damage but only some were successful. To date, the impact of compaction parameters such as precompression and tableting rate on sustained release MUPS tablets remain not well explored. In this presentation, the impact of altering how the MUPS tablets was produced was evaluated, and various benefits could be demonstrated.