Unlocking the Potential of Biomacromolecules: A Journey from Novel Drug Delivery Systems to Regenerative Medicine

Precision molecules are inevitable to design and control biological function in pharmacy and medicine. Proteins as tectons (architectural building blocks) enable high molecular precision using various design approaches. Here the use of designable structural protein motives derived from elastin-like proteins are used to create a modular library of over 800 sequence building blocks enabling access to block-domain proteins for: I) amphiphilic proteins mimicking the function of membrane phospholipids – with uses for novel drug formulation strategies and the design of de novo organelles and protocells. II) adaptive material properties used in 4D printing and the creation of artificial extracellular protein matrices for applications in tissue replacement and wound-closure.